• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Nasal powder delivery device (100) comprising a reservoir (110) containing at least one dose of powder, a nasal dispensing head (120) for insertion into a nostril of a user, said nasal dispensing head having a dispensing orifice (121), and an air flushing (130) generating, upon actuation of said nasal powder dispensing device (100), a flow of compressed air to dispense a dose of powder into said nostril to through said dispensing orifice (121), said flushing comprising an air chamber (131) and a piston (132) sealingly slidable in said air chamber (131) for compressing the air contained in said air chamber (131); air chamber (131), said nasal powder delivery device (100) having the following properties: - a pressure of said compressed air flow generated by said flush (130) greater than 0.7 bar; and a volume of said air chamber (131) greater than 1700 mm 3.
    公开号:FR3046552A1
    申请号:FR1650118
    申请日:2016-01-07
    公开日:2017-07-14
    发明作者:Franck Poullain；Olivier Michelet；Guillaume Brouet
    申请人:Aptar France SAS；
    IPC主号:
    专利说明:

    The present invention relates to a device for nasal distribution of powder.
    Nasal powder delivery devices are well known. They generally comprise a reservoir containing one or more doses of powder, dispensing means, and a nasal dispensing head intended to be inserted into a nostril of a user, said nasal dispensing head having a dispensing orifice. The dispensing means generally comprise an air flush. When the dispensing device is actuated, a dose of powder is dispensed into a nostril of the user.
    A disadvantage with these devices of the prior art is the distribution of the dose of powder in the nostril.
    The figure schematically illustrates such a nostril. This includes the nasal orifice 1 (sometimes called the nose), the nasal valve 2, the inferior turbinate 3, the intermediate horn 4 and the upper horn 5, the frontal sinus 6, the ethmoid 7, the sphenoidal sinus 8, the Turkish saddle 9, the choane 10, the cavum 11, the Eustachian tube 12, the soft palate 13, the soft palate 14 and the hard palate 15.
    The nasal valve has a particular geometry. It extends about 1 cm deep and has a vertical longitudinal section of about 3 to 4 cm and a width of about 1 to 3 mm. After the passage of the nasal valve, the nasal cavity includes a larger cavity (about 7 cm high and 2 to 3 cm wide). The horns face the nasal valve. Above the cornets is the ceiling of the nasal cavity, including the ethmoid, olfactory bulb and olfactory nerve.
    Since the nasal dispensing devices are not or only slightly invasive, the dispensed powder does not generally pass through the nasal valve 2. Thus, because of the anatomy of the nasal valve 2 and the protective location of the horns 3, 4, 5 the axial or rectilinear trajectory of the particles of the powder spray does not make it possible to reach the ceiling of the nasal cavity, and in particular the ethmoid 7.
    The present invention aims to provide a nasal powder dispensing device that does not reproduce the aforementioned drawbacks.
    It is another object of the present invention to provide a nasal powder delivery device which improves the percentage of the dose that reaches the ethoids.
    The present invention also aims to provide a nasal powder dispensing device that is simple and inexpensive to manufacture and assemble.
    The subject of the present invention is therefore a device for nasal distribution of powder comprising a reservoir containing at least one dose of powder, a nasal dispensing head intended to be inserted into a nostril of a user, said nasal dispensing head comprising an orifice of dispensing, and a generating air flush, upon actuation of said nasal powder dispensing device, a flow of compressed air to dispense a dose of powder into said nostril through said dispensing orifice, said flush of air comprising an air chamber and a piston sealingly slidable in said air chamber for compressing the air contained in said air chamber, said nasal powder dispensing device having the following properties: - a pressure of said flow of air compressed air generated by said flushing greater than 0.7 bar; and a volume of said air chamber greater than 1700 mm 3.
    Advantageously, said pressure is less than 2 bar.
    Advantageously, said pressure is between 1 and 1.5 bar.
    Advantageously, said pressure is approximately 1.3 bar.
    Advantageously, said volume is less than 3000 mm 3.
    Advantageously, said volume is between 2000 and 2700 mm3.
    Advantageously, said volume is approximately 2600 mm 3.
    Advantageously, said dose of powder is 10 mg.
    Advantageously, the average particle size of the powder dose is greater than 5 μm.
    Advantageously, said reservoir contains a single dose of powder, distributed during a single actuation of said nasal powder dispensing device.
    Advantageously, said nasal powder dispensing device comprises a plurality of reservoirs, each containing a single dose of powder.
    These and other features and advantages will appear more clearly in the following detailed description, made with reference to the accompanying drawings, given by way of non-limiting examples, and in which: FIG. 1 is a schematic view of a Fig. 2 is a schematic view of a nasal powder delivery device adapted for the present invention; and Fig. 3 is a graph illustrating the powder depositions in the different areas of the nostril according to the volume of the nostril. flushing and the pressure generated by said flushing.
    In the description, the terms "axial" and "radial" refer in particular to the longitudinal direction of the device shown in Figure 2. The terms "proximal" and "distal" refer to the dispensing orifice of said device. The invention applies more particularly to devices of the unidose type powder such as that shown in Figure 2. Of course, other types of nasal powder distribution devices are also conceivable.
    The device 100 shown in FIG. 2 comprises a reservoir 110 containing a dose of powder. Devices with a reservoir containing more than one dose are possible. Likewise, devices comprising several reservoirs each containing a single dose are also possible. A nasal dispensing head 120 is assembled on said reservoir 110, said head being intended to be inserted into a nostril of a user. Said nasal dispensing head comprises a dispensing orifice 121. The device 100 further comprises an air flushing 130 generating, upon actuation of said device 100, a flow of compressed air for dispensing a dose of powder into said nostril through said dispensing orifice 121. Said air flushing comprises an air chamber 131 and a piston 132 sealingly sliding in said air chamber 131 for compressing the air contained in said air chamber 131 and thus generating said flow of compressed air.
    In the example shown in FIG. 2, the reservoir 110 is formed by a hollow tube 111 open at its two axial ends, and closed at its proximal end by a closure element 112, such as a ball, and closed at its end. distal end by an insert 115. This insert 115 has an axial extension rod, and may, upon actuation, slide in said hollow tube 111 to drive said closure member 112 out of its closed position. In this example, the piston 132 of the air flushing 130 is integral with an axial projection 135 which extends in the proximal direction, and which, during actuation, will move together with the piston 132 during the compression of the air contained in the air chamber 131. When said projection 135 of the piston 132 comes into contact with said insert 115 of the tank 110, a continuation of the displacement of the piston 132 will cause the sliding of said insert 115 in said hollow tube 111 out of its closed position. Said insert 115 will on the one hand open the passage between the flush 130 and the tank 110 and on the other hand cause the expulsion of the closure element 112. Thus, the compressed air in the chamber of air 131 will flow into said reservoir and cause the dose of powder out of said reservoir towards said dispensing orifice 121. The documents WO9946055 and WO2015001281 describe devices of this type. Of course, other types of devices are also possible.
    According to the invention, the device for nasal distribution of powder 100 has the following properties: a pressure of said flow of compressed air generated by said flushing 130 greater than 0.7 bar, advantageously less than 2 bar, advantageously included between 1 and 1.5 bar, preferably about 1.3 bar; and a volume of said air chamber 131 greater than 1700 mm 3, advantageously less than 3000 mm 3, advantageously between 2000 and 2700 mm 3, preferably around 2600 mm 3.
    This combination of pressure and flush volume optimizes the rate of powder deposition on ethoids.
    FIG. 3 illustrates comparative tests which demonstrate, for the same dispensing device and for the same dose of 10 mg powder: with an identical pressure of 0.7 bar, a volume of 2000 mm 3 provides a better deposition rate at ethmoid level, compared with volumes of 1300 and 1700 mm3; with an identical volume of 2000 mm 3, a pressure of 1 bar provides a better deposition rate at the level of the ethoids, compared with a pressure of 0.7 bar; with an identical volume of 2600 mm 3, a pressure of 1.3 bar provides a better deposition rate at the level of the ethoids, compared with a pressure of 1 bar; the best deposition rate at the ethmoid level, about 35%, is obtained with a volume of 2600 mm 3 and a pressure of 1.3 bar.
    It can be noted that the pressure and volume values of the flushing can be dependent on the dose of powder dispensed, and that the maximum values can be limited by the inconvenience to the user and an actuation of the dispensing device. which must not be too difficult.
    In a known manner for a nasal distribution of powder, it is desirable that the average particle size of the powder dose is greater than 5 μm.
    The present invention has been described with reference to an advantageous embodiment, but it is understood that a person skilled in the art can make any modifications, without departing from the scope of the present invention as defined by the appended claims.
    权利要求:
    Claims (11)
    [1" id="c-fr-0001]
    claims
    1. - Nasal powder delivery device (100) comprising a reservoir (110) containing at least one dose of powder, a nasal dispensing head (120) intended to be inserted into a nostril of a user, said dispensing head nasal chamber having a dispensing orifice (121), and an air flushing (130) generating, upon actuation of said nasal powder dispensing device (100), a flow of compressed air to dispense a dose of powder into said nostril through said dispensing orifice (121), said flushing comprising an air chamber (131) and a piston (132) sealingly slidable in said air chamber (131) to compress the air contained in said air chamber (131), characterized in that said nasal powder delivery device (100) has the following properties: - a pressure of said compressed air flow generated by said upper air flush (130) at 0.7 bar; and a volume of said air chamber (131) greater than 1700 mm 3.
    [2" id="c-fr-0002]
    2. - Device according to claim 1, wherein said pressure is less than 2 bar.
    [3" id="c-fr-0003]
    3. - Device according to claim 1 or 2, wherein said pressure is between 1 and 1.5 bar.
    [4" id="c-fr-0004]
    4. - Device according to any one of the preceding claims, wherein said pressure is about 1.3 bar.
    [5" id="c-fr-0005]
    5. - Device according to any one of the preceding claims, wherein said volume is less than 3000 mm3.
    [6" id="c-fr-0006]
    6. - Device according to any one of the preceding claims, wherein said volume is between 2000 and 2700 mm3.
    [7" id="c-fr-0007]
    7. - Device according to any one of the preceding claims, wherein said volume is about 2600 mm3.
    [8" id="c-fr-0008]
    8. - Device according to any one of the preceding claims, wherein said dose of powder is 10 mg.
    [9" id="c-fr-0009]
    9. - Device according to any one of the preceding claims, wherein the average particle size of the powder dose is greater than 5 pm.
    [10" id="c-fr-0010]
    10. - Device according to any one of the preceding claims, wherein said reservoir (110) contains a single dose of powder, distributed during a single actuation of said nasal powder dispensing device (100).
    [11" id="c-fr-0011]
    The device of claim 10, wherein said nasal powder delivery device (100) includes a plurality of reservoirs (110), each containing a single dose of powder.
    类似技术:
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    同族专利:
    公开号 | 公开日
    WO2017118827A1|2017-07-13|
    JP2019500974A|2019-01-17|
    EP3400047B1|2019-11-20|
    EP3400047A1|2018-11-14|
    US20190358417A1|2019-11-28|
    CN108430552A|2018-08-21|
    CN108430552B|2020-07-31|
    FR3046552B1|2018-02-16|
    引用文献:
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    法律状态:
    2017-01-25| PLFP| Fee payment|Year of fee payment: 2 |
    2017-07-14| PLSC| Publication of the preliminary search report|Effective date: 20170714 |
    2018-01-29| PLFP| Fee payment|Year of fee payment: 3 |
    2020-01-28| PLFP| Fee payment|Year of fee payment: 5 |
    2021-01-26| PLFP| Fee payment|Year of fee payment: 6 |
    2022-01-27| PLFP| Fee payment|Year of fee payment: 7 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1650118A|FR3046552B1|2016-01-07|2016-01-07|NASAL POWDER DISTRIBUTION DEVICE.|
    FR1650118|2016-01-07|FR1650118A| FR3046552B1|2016-01-07|2016-01-07|NASAL POWDER DISTRIBUTION DEVICE.|
    PCT/FR2017/050040| WO2017118827A1|2016-01-07|2017-01-06|Nasal delivery device for a powder|
    CN201780005893.0A| CN108430552B|2016-01-07|2017-01-06|Nasal powder dispensing device|
    US16/067,862| US20190358417A1|2016-01-07|2017-01-06|Nasal delivery device for a powder|
    EP17711702.5A| EP3400047B1|2016-01-07|2017-01-06|Nasal delivery device for a powder|
    JP2018535299A| JP2019500974A|2016-01-07|2017-01-06|Nasal powder administration device|
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